Céline Marionneau

 

In this program, our objectives are :

  • to identify novel phosphorylation and other post-translational modification sites on Nav1.5 and its accessory/regulatory proteins using proteomic approaches performed from native cardiac tissues; and,
  • to decipher the role of these sites in the post-translational regulation of Nav1.5 channels by performing biochemical and electrophysiological analyses in freshly isolated cardiomyocytes genetically modified with adenoviruses.
 

Funding

  • Grant from "la Fondation d’entreprise Genavie" (2019-2020): Phosphoproteomic analysis of cardiac Nav1.5 channels under β-adrenergic stimulation
  • Grant from the Agence Nationale de la Recherche (2016-2020, ANR-DFG, Progress DHF, ANR-16-CE92-0013-01, with Lars Maier, University Hospital Regensburg, Germany, as co-principal investigator)

Most relevant publications

Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C.
Proteomic analysis of native cerebellar iFGF14 complexes.
Channels (Austin) 10: 297–312, 2016

Burel S, Coyan FC, Lorenzini M, Meyer MR, Lichti CF, Brown JH, Loussouarn G, Charpentier F, Nerbonne JM, Townsend RR, Maier LS, Marionneau C.
C-terminal phosphorylation of NaV1.5 impairs FGF13-dependent regulation of channel inactivation.
J Biol Chem 292: 17431–17448, 2017.

Marionneau C, Abriel H.
Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications.
J Mol Cell Cardiol 82: 36–47, 2015.

Marionneau C, Abriel H.
Cardiac Sodium Current Under Sympathetic ControlProtein Phosphatase 2A Regulates Cardiac Na+ Channels.
Circ Res 124: 674–676, 2019.