Benjamin Lauzier, Bertrand Rozec, Michel De Waard

Septic shock is associated with acute cardiac dysfunction and a high rate of mortality.

Our aim here is to identify by mass spectrometry key proteins secreted in blood in response to septic shock, which may promote cardiac dysfunction.

We will also test whether the stimulation of O-GlcNAcylation at the early phase of septic shock is associated with an improvement of cardiovascular function, and a reduction in organ failure and mortality.