Alexandre Paccalet, Lyon University

Abstract 

A growing body of evidence indicates that the bone marrow is not merely a source of immune cells but an active regulator of cardiovascular health. The talk will discuss recent discoveries revealing how cardiovascular stress and protective interventions remodel the bone marrow microenvironment, thereby influencing hematopoietic stem cell behavior and systemic inflammation. Particular emphasis will be placed on metabolic adaptations within the niche and their consequences for immune cell production. Together, these studies support the existence of a bone marrow-heart axis that may offer new opportunities for therapeutic intervention across a broad spectrum of cardiovascular diseases.

Biography

Alexandre Paccalet, is a cardiovascular immunometabolism researcher specializing in inflammation and immune regulation. He earned his PhD in Lyon under the mentorship of Pr Ovize, investigating cardiac myocyte–macrophage interactions during myocardial infarction. Following this, he completed a postdoctoral fellowship at Harvard Medical School in Pr Nahrendorf’s lab, where he studied bone marrow niche modulation in cardiovascular diseases and exercise. Supported by a Marie Skłodowska-Curie fellowship, Alexandre returned to Europe to develop his research at the CarMeN lab (UMR1060) and Hospices Civils de Lyon. In 2026, he will establish his independent research group through the INSERM ATIP Avenir program, focusing on how monocyte metabolism drives cardiovascular disease progression and exploring novel therapeutic strategies.