Frédéric Jaisser, The Cordeliers Research Center, Paris

The aim of his studies is to improve the understanding of the pathophysiological roles and signaling pathways whereby the hormone aldosterone promotes pathologies in various organs including the kidney and the cardiovascular system but also eye, skin and liver. His work combines cellular and molecular approaches, animal physiology, pharmacological studies and has implications in human diseases. His interest includes translational research aimed to identify and validate biomarkers of Mineralocorticoid Receptor activation in cardiovascular and kidney diseases and novel therapeutic use of MR antagonists.
In the past years he focused his research on the impact of various MR antagonists, including the non-steroidal MRAs finerenone, on the cardiovascular impact of chronic kidney disease and/or progression of renal failure. He identified novel signaling pathways such as the Neutrophil Gelatinase-Associated Lipocalin as a major underlying mechanism in fibrotic and inflammatory consequences of MR activation in renal and cardiovascular diseases.

Biography

Frederic JAISSER, MD, PhD got a permanent position as Director of Research at the National Institute of Health and Medical Research (INSERM) in 1996.  Dr. JAISSER received his medical training and degrees from the Reims Medical School France and was qualified as Nephrologist in 1990. Since 2009 he managed a team of the INSERM Unit U1138, at the Cordeliers Research Centre, Paris and since July 2024 he is Deputy Director of the MEDICIS lab (Metabolic diseases, Diabetes and comorbidities) in the INSERM Unit U1166, Medicine Faculty, la Pitié-Salpétrière  Hospital, Paris. Since 2022 he is president of the INSERM Specialized Scientific Committee Pathophysiology CSS3.