Jean-Philippe Pradère, University of Paul Sabatier

On 02 February 2024

Amphi DE

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11h30

Mitochondria morphology/function across aging

Mitochondria morphology/function across aging

Jean-Philippe Pradère, PhD, CRCN Inserm
Institut RESTORE, UMR 1301, INSERM, CNRS-Université Paul Sabatier, Université de Toulouse

Abstract

We aim to study mitochondria heterogeneity in several tissues clinically related to aging especially blood and skeletal muscles. We investigated whether mitochondria size heterogeneity is related to ultrastructural heterogeneity and associated with mitochondria dysfunctions. Based on functional analysis, we studied if mitochondria size heterogeneity is related to a functional heterogeneity and demonstrated that certain mitochondrial subpopulations may play a detrimental role in physiology while others may rather exert a protective role.

Biographie

After a PhD on adipose tissue and renal fibrosis at i2MC in Toulouse, and post-doctoral fellowship abroad on liver fibrosis and cancer, JPP has now focused his research on metabolism and ageing at the Restore institute in Toulouse where he still worked on liver, macrophages and metabolic disorders and has in parallel developed projects using mice and fish models (zebrafish and killifish).

Updated on 06 December 2023.