Jeanne Nerbonne, Washington University, St Louis, USA
-
On 27 June 2025Amphi DEfalse false
-
11h30
Defining the Mechanisms Controlling Repolarization and Remodeling in the Mammalian Heart…One K+ Channel at a Time
Defining the Mechanisms Controlling Repolarization and Remodeling in the Mammalian Heart…One K+ Channel at a Time
Jeanne M. Nerbonne, PhD,
Alumni Endowed Professor of Molecular Biology and Pharmacology,
Nerbonne Lab, Washington University in St. Louis, USA
Abstract
Research in the Nerbonne lab explores the molecular, cellular and systemic mechanisms involved in the regulation of voltage-gated K+ (Kv) and Na+ (Nav) channels that shape cardiac and neuronal action potentials, the critical determinants of signaling and cell-cell communication in the cardiovascular and nervous systems. She and her colleagues have provided critical insights into the mechanisms contributing to the diversity of native cardiac and neuronal Kv and Nav channels, the roles of these channels in controlling normal physiology and behavior, and the functional impact of derangements in channel expression/properties associated with inherited and acquired disease.
Biography
Jeanne Nerbonne received a B.S. in Chemistry from Framingham State College and a Ph.D. in Physical Organic Chemistry from Georgetown University. After completing postdoctoral training at the California Institute of Technology, she joined the Department of Pharmacology at Washington University Medical School. She is presently the Alumni Endowed Professor of Molecular Biology and Pharmacology in the Departments of Medicine, Developmental Biology and Biomedical Engineering at Washington University. She was the Director of the Center for Cardiovascular Research 2013-2023, and Co-Director of the Center for the Investigation of Membrane Excitability Diseases, 2010-present.
