Nicolas Venteclef, INEM, Paris

Nicolas Venteclef, PhD, DR
Group Leader
Immunity and Metabolism of Diabetes
Institut Necker Enfants Malades
Paris

Transcriptomic and Epigenetic processes tightly regulate cellular function in health and disease, such as obesity and type 2 diabetes.  Recent studies from IMMEDIAB have allowed detailed characterization of the transcriptional circuits underlying monocyte and macrophage regulation.  I will present new insights about how specific epigenomic modifiers control tissue macrophage plasticity and its consequences in tissue homeostasis and type 2 diabetes.  

Biography

After completing my Ph.D. in GlaxoSmithKline Laboratory in 2007, I joined the Karolinska Institutet (Stockholm, Sweden) in the Department of Biosciences and Nutrition Medicine as a postdoc in the laboratory of Profs E. Treuter and J.A. Gustafsson from 2008 to 2010. In 2011, I obtained an Inserm position (CR) in the laboratory of Prof. K. Clement in the Cordeliers research centre (Paris, France).  In 2016, I became DR Inserm and started my own group “Immunity and Metabolism of Diabetes” in Cordeliers research centre to study the epigenomic and transcriptomic mechanisms involved in the regulation of metabolic inflammation in diabetes. From January 2022, I joined INEM as group leader of the team “Immunity and Metabolism of Diabetes”, IMMEDIAB.