Noam Zelcer, University of Amsterdam, The Netherlands
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Le 18 October 2024Amphi DEfalse false
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11h30
A new SPRING in lipid metabolism
A new SPRING in lipid metabolism
Noam Zelcer, PhD
Zelcer LAB - The Netherlands
The Zelcer lab is located in the Department of Medical Biochemistry in the the Academic Medical Center (AMC) of the University of Amsterdam. The lab is a member of both the Amsterdam Cardiovascular Sciences (ACS) and Amsterdam Gastroenterology, Endocrinology, and Metabolism (AGEM) research institutes. It mission is to uncover the fundamental mechanisms underlying the molecular regulation of lipid metabolism in health and disease. They study this in the context of cardio-metabolic disease using genetic, biochemical, cellular, and animal models.
Abstract
Cellular and whole-body lipid homeostasis is controlled by a multitude of transcriptional and post-transcriptional mechanisms. Herein, the Sterol Regulatory Element Binding Proteins (SREBPs) play a central role as the master regulators of cholesterol and fatty acid metabolism. The transcriptional activation of SREBPs involves a series of trafficking and proteolytic events that have been extensively characterized in the last two decades. Using a genome-wide functional genetic screen the Zelcer group has recently discovered that the uncharacterized gene, SPRING (also known as C12ORF49), is a new core component of the SREBP activation machinery. New insights into the critical role that SPRING plays in governing SREBPs in cells and in vivo, its mechanism of action, and structural basis for regulation of SREBPs will be presented.Biography
Noam Zelcer is a Professor in the Department of Medical Biochemistry at the Academic Medical Center (AMC) of the University of Amsterdam. He studied pharmacology at the Hebrew University in Jerusalem, Israel, before moving to the Netherlands to pursue doctoral research at the Netherlands Cancer Institute where he graduated in 2003. He did his post-graduate training on the transcriptional and post-transcriptional regulation of cholesterol metabolism at the University of California in Los Angeles. In 2009 he returned to The Netherlands to lead a research group in the AMC, and in 2016 he was appointed as full Professor. His research focuses primarily on the (post)-transcriptional regulation of lipid metabolism in cardio-metabolic diseases.
