Séminaire de Laurent REBER, PhD - Paris

Deciphering the contribution of antibody subclasses, Fc receptors and myeloid cells in allergic shock

ABSTRACT

Allergic shock (anaphylaxis) is the most dramatic manifestation of allergy. The current paradigm in human states that in most cases, anaphylaxis is driven by IgE antibodies, mast cells and histamine. We have developed multiple mouse models of anaphylaxis to study in details the pathways leading to allergic shock reactions. Our data indicate that while IgE and mast cells contribute to anaphylaxis in some models, ‘alternative’ pathways mediated by IgG antibodies, Fcg receptors, myeloid cells and platelet-activating factor (PAF) play a dominant role in anaphylaxis. We are now assessing the clinical relevance of our findings using ‘humanized’ models of anaphylaxis, with a particular focus on the role of human IgG in anaphylaxis.