Vincent Gache, Institut NeuroMyoGène, Lyon
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Le 31 January 2025Amphi DEfalse false
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11h30
Interplay between cytoskeleton network regulation during muscle development and muscle function
Interplay between cytoskeleton network regulation during muscle development and muscle function
Vincent Gache, PhD, Inserm Team Leader
Institut NeuroMyogène (INMG-PGNM)
CNRS/UCBL1 UMR 5261 - INSERM U1315
Lyon
Abstract
Unlike the textbook reported idea that the nucleus “floats” at the cell centroid and is mainly presented as an envelope protecting the DNA, nuclear positioning is a highly dynamic process. The positioning of myonuclei in a large post-mitotic syncytium, with hundreds of myonuclei, is an even more challenging process. It is still puzzling how myonuclei position, remain anchored in specific locations along mature mammalian skeletal muscle fibers and what are the functional consequences of myonuclei positioning alterations. The overall goal of our team is to understand, in the context of the muscle cells, how various cytoskeletons networks are spatially remodel along muscle formation/maturation and how their interplay act on muscle cells destiny. More specifically, our leading project aim to decipher how the microtubule network settings control spatially organelle trafficking, myonuclei repartition, gene expression and muscle cells functionality in healthy and pathological contexts.
