Personnel de l'université

Patricia LEMARCHAND

Professeure des Universités/biologie cellulaire - Praticien Hospitalier/pneumologue

Coordonnées

l'institut du thorax - Inserm UMR 1087/CNRS UMR 6291, IRS-Université de Nantes, 8 quai Moncousu, BP 70721, 44007 Nantes cedex 1, France

Tél
0228080133 (n° interne : 320133)
Mail
Patricia.Lemarchand@univ-nantes.fr

Discipline(s) enseignée(s)

Biologie cellulaire

Thèmes de recherche

Thérapie cellulaire (recherche translationnelle, de la cellule souche aux essais cliniques).

Modélisation et étude de pathologies à partir de cellules souches iPSCs.

Etude de l'interface entre la recherche biologique et la pratique médicale (travail en collaboration avec Stéphane Tirard, Centre François Viète).

Sexe, genre et santé.

Activités / CV

Informations complémentaires

Principales publications récentes :

Benkalfate N, Eschapasse E, Georges T, Leblanc C, Dirou S, Melscoet L, Chéné A-L, Horeau-Langlard D, Bry C, Chambellan A, Nicolas A, Defrance C, Liberge R, Karakachoff M, Hardouin JB, Blanc FX, Lemarchand P. Evaluation of the Post COVID-19 Functional Status (PCFS) scale in a cohort of patients recovering from hypoxemic SARS-CoV-2 pneumonia. BMJ Open Respiratory Research 2022;9:e001136.
 
Al Sayed ZR, Jouni M, Gourraud JB, Nadjet Belbachir N, Barc J, Girardeau A, Forest F, Derevier A, Gaignerie A, Chariau C, Cimarosti B, Canac B, Olchesqui P, Charpentier E, Schott JJ, Redon R, Isabelle Baró I, Probst V, Charpentier F, Loussouarn G, Zibara K, Lamirault G, Lemarchand P*, Gaborit N*. A consistent arrhythmogenic trait in Brugada syndrome cellular phenotype. Clinical and Translational Medicine 2021;11(6):e413. *co-auteures correspondantes.

Al Sayed ZR, Canac R, Cimarosti B, Bonnard C, Hamamy H, Kayserili H, Girardeau A, Jouni M, Jacob N, Gaignerie A, Chariau C, David L, Forest V, Marionneau C, Loussouarn G, Lamirault G, Reversade B, Zibara K,
Lemarchand P*, Gaborit N*. Human model of IRX5 mutations reveals key role for this transcription factor in ventricular conduction. Cardiovascular Research 2021; 117:2092-2107. *co-auteures correspondantes.
 

De Waard S, Montnach J, Cortinovis C, Chkir O, Erfanian M, Hulin P, Gaborit N, Lemarchand P, Mesirca P, Bidaud I, Mangoni M, De Waard M, Ronjat M. Maurocalcin analogue MCaE12A facilitates Ca2+ mobilization in cardiomyocytes. Biochemical Journal 2020; 477:3985-3999.

De Waard S, Montnach J, Ribeiro B, Nicolas S, Forest V, Charpentier F, Mangoni M, Gaborit N, Ronjat M, Loussouarn G, Lemarchand P, De Waard M. Functional impact of BeKm-1, a high affinity hERG blocker, on cardiomyocytes derived from human-induced pluripotent stem cells. International Journal of Molecular Sciences 2020; 21:7167-7171.

Dirou S, Chambellan A, Chevallier P, Germaud P, Lamirault G, Gourraud PA, Perrot B, Delasalle B, Forestier B, Guillaume T, Peterlin P, Garnier A, Magnan A, Blanc FX, Lemarchand P. Deconditioning, fatigue and impaired quality of life in long-term survivors after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplantation 2018; 53: 281-290.

Lamirault G, de Bock E, Sébille S, Delasalle B, Roncalli J, Susen S, Piot C, Trochu JN, Teiger E, Neuder Y, Le Tourneau T, Manrique A, Hardouin J-B, Lemarchand P. Sustained quality of life improvement after intracoronary injection of autologous bonemarrow cells in the setting of acute myocardial infarction: results from the BONAMI trial. Quality of Life Research 2017; 26:121-125.

Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller M-A, Sagan C, Magnan A, Lemarchand P. Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma. Stem Cells 2016; 209:258-265.

Es-Salah-Lamoureux Z, Jouni M,Malak OA, Belbachir N, Reda Al Sayed Z, Gandon-Renard M, Lamirault G, GauthierC, Baró I, Charpentier F, Zibara K, Lemarchand P, Beaumelle B, Gaborit N, Loussouarn G. HIV-Tat induces a decrease in IKr and IKs via reduction in phosphatidylinositol-(4,5)-bisphosphate availability. Journal of Molecular and Cellular Cardiology 2016; 99:1-13.

Si-Tayeb K, Idriss S, Champon B, Caillaud A, Pichelin M, Arnaud L, Lemarchand P, Le May C, Zibara K, Cariou B. Urine sample-derived human induced pluripotent stem cells as a model to study PCSK9-mediated autosomal dominant hypercholesterolemia. Dis Mod & Mechanisms  2016;9(1):81-90.

Guijarro D, Lebrin M, LairezO, Bourin P, Piriou N, Pozzo J, Landes G, Berry M, Letourneau T, Cussac D, Sensebe L, Gross F, Lamirault G, Huynh A, Manrique A, Ruidavet JB, Elbaz M, Trochu JN, Parini A, Kramer S, Galinier M, Lemarchand P, Roncalli J. Intramyocardial transplantation of mesenchymal stromal cells for chronic myocardial ischemia and impaired left ventricular function: Results of theMESAMI 1 pilot trial. International Journal of Cardiology 2016; 209:258-265.

Jouni M, Si-Tayeb K, Es-Salah-Lamoureux Z, Latypova X, Champon B, Caillaud A, Rungoat A, Charpentier F, Loussouarn G, Baró I, Zibara K, Lemarchand P, Gaborit N. Towards Personalized Medicine: Using cardiomyocytes differentiated from urine-derived pluripotent stem cells to recapitulate electrophysiological characteristics of LQT2 syndrome. J Am Heart Assoc 2015;4:e002159.

Gyongyosi M, Wojakowski W, Lemarchand P, et al. Meta-Analysis of Cell-basedCaRdiac stUdiEs (ACCRUE) in patients with acute myocardial infarction based on individual patient data. Circ Res 2015 16(8):1346-60. Best manuscript award 2015.

Lamirault G, Susen S, Forest V, Hemont C, Parini A, Le Corvoisier P, Piot C, Richard MJ, Delasalle B, Rouard H, Sportouch C, Persoons V, Van Belle E, Roncalli J, Lemarchand P. Differential mobilization of progenitor cells in smoker and non-smoker patients with acute myocardial infarction: insights from the BONAMI biology sub-study. Stem Cell Res & Ther 2013; 4:152.

Roncalli J, Mouquet F, Piot C, Trochu JN, Le Corvoisier P, Neuder Y, Le Tourneau T, Agostini D, Gaxotte V, Sportouch C, Galinier M, Crochet D, Teiger E, Richard MJ, Polge AS, Beregi JP, Manrique A, Carrie D, Susen S, Klein B, Parini A, Lamirault G, Croisille P, Rouard H, Bourin P, Nguyen JM, Delasalle B, Vanzetto G, Van Belle E, Lemarchand P. Intracoronary autologous mononucleated bone marrow cell infusion for acute myocardial infarction:  results of the randomized multicenter BONAMI Trial. Eur Heart J 2011; 32(14): 1748-1757.