ANR MINERAL : Thibaut Quillard (2025-2027)

Thibaut Quillard is the French leader of this European collaborative project: Cytoskeleton Dynamics and Extracellular Vesicles in Arterial Calcification.

Calcification of atherosclerotic lesions is an independent predictive factor for cardiovascular complications and death, by affecting locally plaque stability, thrombus formation, endovascular treatment success, and more globally by greatly impacting vascular rigidity and vascular blood system resistanc

With a german group led by Dr Claudia Goettsch, we are coordinating a European research project aiming at deciphering the role of cytoskeleton and extracellular vesicles (EVs) trafficking and loadout in this process. We’ll more specifically investigate EVs isolated from calcified atherosclerotic lesions to identify pro-mineralizing EV subsets, and characterize their miRNA and protein content. We’ll also test the direct impact of these miRNAs on SMC mineralization in vitro and how their loading into EVs affect their functional role on vascular calcification in vitro and in vivo