Selected Publications

Bourcier R, Le Scouarnec S, Bonnaud S, Karakachoff M, Bourcereau E, Heurtebise-Chrétien S, Menguy C, Dina C, Simonet F, Moles A, Lenoble C, Lindenbaum P, Chatel S, Isidor B, Génin E, Deleuze J-F, Schott J-J, Le Marec H, ICAN Study Group, Loirand G, Desal H, Redon R.
Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm.
Am J Hum Genet 2018;102:133–141.

André-Grégoire G, Dilasser F, Chesné J, Braza F, Magnan A, Loirand G, Sauzeau V.
Targeting of Rac1 prevents bronchoconstriction and airway hyperresponsiveness.
J Allergy Clin Immunol 2017;doi:10.1016/j.jaci.2017.09.049.
 
Aureille J, Belaadi N, Guilluy C.
Mechanotransduction via the nuclear envelope: a distant reflection of the cell surface.
Curr Opin Cell Biol 2017;44:59–67.

Barrera-Chimal J, André-Grégoire G, Nguyen Dinh Cat A, Lechner SM, Cau J, Prince S, Kolkhof P, Loirand G, Sauzeau V, Hauet T, Jaisser F.
Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1.
J Am Soc Nephrol 2017;28:1216–1226.

Bourcier R, Chatel S, Bourcereau E, Jouan S, Marec HL, Daumas-Duport B, Sevin-Allouet M, Guillon B, Roualdes V, Riem T, Isidor B, Lebranchu P, Connault J, Tourneau TL, Gaignard A, Loirand G, Redon R, Desal H, ICAN Investigators.
Understanding the Pathophysiology of Intracranial Aneurysm: The ICAN Project.
Neurosurgery 2017;80:621–626.
 
Carbone ML, Chadeuf G, Heurtebise-Chrétien S, Prieur X, Quillard T, Goueffic Y, Vaillant N, Rio M, Castan L, Durand M, Baron-Menguy C, Aureille J, Desfrançois J, Tesse A, Torres RM, Loirand G.
Leukocyte RhoA exchange factor Arhgef1 mediates vascular inflammation and atherosclerosis.
J Clin Invest 2017;127:4516–4526.
Castan L, Magnan A, Bouchaud G.
Chemokine receptors in allergic diseases.
Allergy 2017;72:682–690.

Claude M, Bouchaud G, Lupi R, Castan L, Tranquet O, Denery-Papini S, Bodinier M, Brossard C.
How Proteins Aggregate Can Reduce Allergenicity: Comparison of Ovalbumins Heated under Opposite Electrostatic Conditions.
J Agric Food Chem 2017;65:3693–3701.

Joubert M, Jagu B, Montaigne D, Marechal X, Tesse A, Ayer A, Dollet L, Le May C, Toumaniantz G, Manrique A, Charpentier F, Staels B, Magré J, Cariou B, Prieur X.
The Sodium-Glucose Cotransporter 2 Inhibitor Dapagliflozin Prevents Cardiomyopathy in a Diabetic Lipodystrophic Mouse Model.
Diabetes. 2017 Apr;66(4):1030-1040.

Randriamboavonjy JI, Rio M, Pacaud P, Loirand G, Tesse A.
Moringa oleifera Seeds Attenuate Vascular Oxidative and Nitrosative Stresses in Spontaneously Hypertensive Rats.
Oxid Med Cell Longev 2017;2017:4129459.

Sauzeau V, Loirand G.
In Vitro and In Vivo Approaches to Assess Rho Kinase Activity.
Methods Mol Biol 2017;1527:213–218.

Braza F, Dirou S, Forest V, Sauzeau V, Hassoun D, Chesné J, Cheminant-Muller MA, Sagan C, Magnan A, Lemarchand P.
Mesenchymal stem cells induce suppressive macrophages through phagocytosis in a mouse model of asthma.
Stem Cells. 2016 ; 34(7):1836-45

Randriamboavonjy JI, Loirand G, Vaillant N, Lauzier B, Derbré S, Michalet S, Pacaud P, Tesse A.
Cardiac Protective Effects of Moringa oleifera Seeds in Spontaneous Hypertensive Rats.
Am J Hypertens. 2016 29(7):873-81

Loirand G.
Rho Kinases in Health and Disease: from Basic Science to Translational Research.
Pharmacol Rev., 2015, 2015; 67(4):1074-95.

Carbone ML, Brégeon J, Devos N, Chadeuf G, Blanchard A, Azizi M, Pacaud P, Jeunemaître X, Loirand G.
Ang II activates the RhoA exchange factor Arhgef1 in humans.
Hypertension, 2015, 65(6):1273-8.

Chesné J, Braza F, Chadeuf  G, Mahay G, Cheminant MA, Brouard S, Sauzeau V, Loirand G, Magnan A.
Prime role of IL-17A in neutrophilia and airway smooth muscle contraction in a house dust mite-induced allergic asthma model.
J Allergy Clin Immunol 2015, 35:1 643-1645.


Loirand G, Sauzeau V, Pacaud P.
Small G proteins in the cardiovascular system: Physiological and pathological aspects.
Physiol Rev. 2013;93(4):1659-720.

Guilluy C, Brégeon J, Toumaniantz G, Rolli-Derkinderen M, Retailleau K, Loufrani L, Henrion D, Scalbert E, Bril A, Torres RM, Offermanns S, Pacaud P, Loirand G.
The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure.
Nat Med, 2010; 16(2):183-90.

Awards 2018-2019

Patents