Extracellular vesicles and inter-organ communication in cardiometabolic diseases (EV-Link)


Soazig Le Lay

 

Investigator : Soazig Le Lay
M2 Student : Maïwenn Taupin
Support staff : Josy-Anne Froger,  Margot Voisin

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Extracellular vesicles (EVs) are heterogeneous membrane nanovesicles secreted into the extracellular medium. They carry biological material (proteins, lipids, nucleic acids, and mitochondria) that can be transferred to target cells, influencing their response and phenotype.

My research group addresses the role of EVs in obesity-associated metabolic complications.

To this aim, we use a translational approach combining in vitro cellular models, preclinical obesity models, and metabolic patient cohorts. Part of my research’s activity takes place in Angers, with a focus on Metabolic dysfunction-Associated SteatoHepatitis (MASH) in collaboration the HIFIH Lab (Univ Angers), in the framework of the FHU GO-NASH.
 

Main findings

Over the past decade, our contribution to understanding EVs’ involvement in adipose tissue (AT) remodeling in obesity include:

Main ongoing projects
  • Use adiponectin enriched-EVs as innovative therapy for diabetes.
  • Identify and develop EV-based biomarkers for cardiometabolic diseases.

Partnership Projects

• Explore EVs as carriers of adipose-stored persistent organic pollutants (POPs) and their effects on MASLD (in collaboration with the HIFIH Lab-Univ Angers, IRSET-Univ Rennes, Laberca-ONIRIS)
• Investigate feces microbiota-derived EVs in MASLD severity (in collaboration with the HIFIH Lab).
 

Learn more about our projects




Extracellular vesicles are carriers of adiponectin with insulin-sensitizing and anti-inflammatory properties. Blandin A, Amosse J, Froger J, Hilairet G, Durcin M, Fizanne L, Ghesquière V, Prieur X, Chaigneau J, Vergori L, Dray C, Pradère JP, Blandin S, Dupont J, Ducluzeau PH, Dubois S, Boursier J, Cariou B, Le Lay S. Cell Rep. 2023 Aug 29;42(8):112866. doi: 10.1016/j.celrep.2023.112866. Epub 2023 Aug 21.

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state.Blandin A, Dugail I, Hilairet G, Ponnaiah M, Ghesquière V, Froger J, Ducheix S, Fizanne L, Boursier J, Cariou B, Lhomme M, Le Lay S. Cell Rep. 2023 Mar 28;42(3):112169. doi: 10.1016/j.celrep.2023.112169. Epub 2023 Mar 1.

Adipocyte-derived extracellular vesicles in health and diseases: Nano-packages with vast biological properties.Le Lay S, Rome S, Loyer X, Nieto L. FASEB Bioadv. 2021 Mar 4;3(6):407-419. doi: 10.1096/fba.2020-00147. eCollection 2021 Jun.

Phenotyping of circulating extracellular vesicles (EVs) in obesity identifies large EVs as functional conveyors of Macrophage Migration Inhibitory Factor. Amosse J, Durcin M, Malloci M, Vergori L, Fleury A, Gagnadoux F, Dubois S, Simard G, Boursier J, Hue O, Martinez MC, Andriantsitohaina R, Le Lay S. Mol Metab. 2018 Dec;18:134-142.

Characterisation of adipocyte-derived extracellular vesicle subtypes identifies distinct protein and lipid signatures for large and small extracellular vesicles. Durcin M, Fleury A, Taillebois E, Hilairet G, Krupova Z, Henry C, Truchet S, Trötzmüller M, Köfeler H, Mabilleau G, Hue O, Andriantsitohaina R, Martin P, Le Lay S. J Extracell Vesicles. 2017 Apr 10;6(1):1305677. doi: 10.1080/20013078.2017.1305677. eCollection 2017

Funding

This program has been supported by :

  • Agence Nationale de la Recherche
  • Fondation Francophone pour la Recherche sur le Diabète (FFRD)
  • Société Francophone du Diabète
  • Fédération Hospitalo-Universitaire, FHU GO-NASH
  • Région Pays de la Loire
  • EU FP7 « LipidomicNet »
  • Genavie




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Mis à jour le 31 mars 2025.