Our overall objective is to understand the signaling mechanisms that control smooth muscle cell functions and their pathogenic dysregulation in vascular and pulmonary pathophysiology. The major goals of our research programs are to identify key proteins as potential therapeutic targets and to speed up clinical application of basic scientific breakthroughs.

Smooth muscle cells are able to acquire pathological phenotypes and functions including excessive contraction, proliferation, migration and exaggerated matrix production, via aberrant activation of the intracellular signaling pathways that control these processes.

Our research projects aim at deciphering these derailed mechanisms through experimental approaches ranging from cellular and transgenic mouse models developed by the team, to studies in humans made possible by close collaboration with clinical services at CHU of Nantes