Biophysics of ion channels
Insvestigator : Gildas Loussouarn, Isabelle Baro, Michel De Waard
Support staff : Anne Bibonne, Béatrice Ollivier,
In our previous works, we have shown, in heterologous expression systems, that intracellular peptides mimicking regions of voltage-gated potassium (Kv7.1, Kv11.1, Kv10.2) and sodium (Nav1.4) channels can modulate the activity of these channels. The next goal is to test a potential therapeutic application. To this end, we will use human cardiomyocytes derived from induced pluripotent stem cells to test whether Kv11.1-specific activating peptides can be used to correct dysfunctions in Kv11.1 (hERG) channels, due to mutations identified in patients presenting with type 2 Long QT syndrome.
Learn more about our projects
- FFC Impulsion : Gildas Loussouarn ( 2025-2026)
AVIN1-Mediated hERG Dynamics: A Novel Mechanism Underlying the Interindividual Variability in Drug-Induced Long QT. Al Sayed ZR, Pereira C, Le Borgne R, Viaris de Lesegno C, Jouve C, Pénard E, Mallet A, Masurkar N, Loussouarn G, Verbavatz JM, Lamaze C, Trégouët DA, Hulot JS.Circulation. 2024 Aug
Predicting hERG repolarization power at 37°C from recordings at room temperature. Oliveira-Mendes BBR, Alameh M, Montnach J, Ollivier B, Gibaud S, Feliciangeli S, Lesage F, Charpentier F, Loussouarn G, De Waard M, Baró I. Clin Transl Med. 2023 May
Editorial: Molecular Mechanisms of Voltage-Gating in Ion Channels. Loussouarn G, Tarek M. Front Pharmacol. 2021, eCollection 2021.
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism. Malak OA, Abderemane-Ali F, Wei Y, Coyan FC, Pontus G, Shaya D, Marionneau C, Loussouarn G. Sci Rep. 2020
Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism. Malak OA, Gluhov GS, Grizel AV, Kudryashova KS, Sokolova OS, Loussouarn G. J Biol Chem 2019
Funding
- Fédération Française de Cardiologie
Updated on 28 July 2025.