Gildas Loussouarn

In this program, we seek to identify peptide sequences controlling the opening of voltage-dependent ion channels involved in cardiac channelopathies, such as Kv7.1 and Kv11.1 potassium channels, and develop therapeutic tools targeting these sites. We also seek to decipher the molecular determinants of the channel/peptides interaction by using the cryo-elecron microscopy technique through collaborations with Olga Sokolova (Lomonosov University, Moscow) and Philippe Moreau (Institut des Matériaux de Nantes). This will help in the design of new therapeutic agent for cardiac arrhythmia. 

Selected publications

hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state.
Malak OA, Es-Salah-Lamoureux* Z, Loussouarn* G.
Sci Rep 2017;7:113.

Detergent-free solubilization of human Kv channels expressed in mammalian cells.
Karlova MG, Voskoboynikova N, Gluhov GS, Abramochkin D, Malak OA, Mulkidzhanyan A, Loussouarn G, Steinhoff H-J, Shaitan KV, Sokolova OS.
Chem Phys Lipids 2019;219:50–57.

Voltage-dependent activation in EAG channels follows a ligand-receptor rather than a mechanical-lever mechanism.
Malak OA, Gluhov GS, Grizel AV, Kudryashova KS, Sokolova OS, Loussouarn G.
J Biol Chem 2019;294:6506–6521.