Céline Marionneau

 

In this program, our objectives are :

  • to identify novel phosphorylation and other post-translational modification sites on Nav1.5 and its accessory/regulatory proteins using proteomic approaches performed from native cardiac tissues; and,
  • to decipher the role of these sites in the post-translational regulation of Nav1.5 channels by performing biochemical and electrophysiological analyses in freshly isolated cardiomyocytes genetically modified with adenoviruses.

Selected publications

Funding

  • Agence Nationale de la Recherche : 2016-2020, ANR-DFG, Progress DHF, ANR-16-CE92-0013-01, with Lars Maier, University Hospital Regensburg, Germany, as co-principal investigator)
  • Fondation d’entreprise Genavie : 2019-2020, Phosphoproteomic analysis of cardiac Nav1.5 channels under β-adrenergic stimulation
ANR
genavie