Cardiac valve disease

Romain Capoulade & Solena Le Scouarnec

 

Investigators: Romain Capoulade, Solena Le Scouarnec, Jean-Jacques Schott, Thierry Le Tourneau, Anne-Sophie Boureau, Patrice Guérin, Jean-Michel Serfaty, Claire Toquet, Jean-Christian Roussel
Post-doc : Margaux Aize
PhD students: Guillaume Guimbretière, Robin Le Ruz, Benjamin Le Vély, Pierre-Guillaume Piriou, Marine Sallé
Support staff: Pascal Aumond, Christian Dina, Pierre Lindenbaum, Florence Kyndt

Cardiac valve diseases are the one of most frequent cardiovascular diseases and are associated with important mobi-mortality. There is currently no medical therapy available to at least slow down the progression of these pathologies, the only option remaining is to replace or repair the diseased valve, via surgical or transcatheter approaches.

In our group, we develop a translational research program, from the genetics and basic researches to the clinical setting, designed to improve our understanding on native valve diseases, such as calcific aortic valve stenosis (CAVS) and mitral valve prolapse (MVP), as well as structural bioprosthetic valve degeneration (SVD).

This program is declined around 3 main axes:

  • One of the largest worldwide cohorts of patients with valve diseases, with the recruitment of sporadic cases and large familial pedigrees.
  • Genetic investigations on familial and isolated cases presenting different degrees of valve diseases.
  • Study of the pathophysiological mechanisms leading to the initiation and progression of these cardiac valve diseases.

We are relying on in-house expertise on multi-omics and high-throughput genetic approaches, on established relevant cellular (primary cell culture and hiPSC) and animal (rodents and large animals) models, and on clinical & pre-clinical multimodal imaging. 


Learn more about our projects :

Polymorphic Size of Lipoprotein(a) and Structural Bioprosthetic Valve Degeneration. Romain Capoulade, Mikaël Croyal, Thomas Senage, Guillaume Guimbretière, Cédric Le May, Arsênio Rodrigues Oliveira, Maxime Carpentier, Nicolas Piriou, Imen Fellah-Hebia, Cristina Costa, Marta Vadori, Manuel Galiñanes, Rafael Manez, Jean-Michel Serfaty, Jean-Paul Soulillou, Emanuele Cozzi, Vered Padler-Karavani, Jean-Christian Roussel, Bertrand Cariou, Thierry Le Tourneau, JACC Cardiovasc Imaging. 2025 Jun

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. Yu Chen H, Dina C, Small AM, Shaffer CM, Levinson RT, Helgadóttir A, Capoulade R, Munter HM, Martinsson A, Cairns BJ, Trudsø LC, Hoekstra M, Burr HA, Marsh TW, Damrauer SM, Dufresne L, Le Scouarnec S, Messika-Zeitoun D, Ranatunga DK, Whitmer RA, Bonnefond A, Sveinbjornsson G, Daníelsen R, Arnar DO, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Hólm H, Ghouse J, Olesen MS, Christensen AH, Mikkelsen S, Jacobsen RL, Dowsett J, Pedersen OBV, Erikstrup C, Ostrowski SR; Regeneron Genetics Center; O'Donnell CJ, Budoff MJ, Gudnason V, Post WS, Rotter JI, Lathrop M, Bundgaard H, Johansson B, Ljungberg J, Näslund U, Le Tourneau T, Smith JG, Wells QS, Söderberg S, Stefánsson K, Schott JJ, Rader DJ, Clarke R, Engert JC, Thanassoulis G. Eur Heart J. 2023 Jun

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model. Delwarde C, Toquet C, Aumond P, Kayvanjoo AH, Foucal A, Le Vely B, Baudic M, Lauzier B, Blandin S, Véziers J, Paul-Gilloteaux P, Lecointe S, Baron E, Massaiu I, Poggio P, Rémy S, Anegon I, Le Marec H, Monassier L, Schott JJ, Mass E, Barc J, Le Tourneau T, Merot J, Capoulade R. Cardiovasc Res. 2023 May

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration.Senage T*, Paul A*, Le Tourneau T*, Fellah-Hebia I, Vadori M, Bashir S, Galiñanes M, Bottio T, Gerosa G, Evangelista A, Badano LP, Nassi A, Costa C, Cesare G, Manji RA, Cueff de Monchy C, Piriou N, Capoulade R, Serfaty JM, Guimbretière G, Dantan E, Ruiz-Majoral A, Coste du Fou G, Leviatan Ben-Arye S, Govani L, Yehuda S, Bachar Abramovitch S, Amon R, Reuven EM, Atiya-Nasagi Y, Yu H, Iop L, Casós K, Kuguel SG, Blasco-Lucas A, Permanyer E, Sbraga F, Llatjós R, Moreno-Gonzalez G, Sánchez-Martínez M, Breimer ME, Holgersson J, Teneberg S, Pascual-Gilabert M, Nonell-Canals A, Takeuchi Y, Chen X, Mañez R, Roussel JC#, Soulillou JP#, Cozzi E#, Padler-Karavani V#. Nat Med. 2022 Feb

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis. Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel M-A, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott J-J, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ. J Am Coll Cardiol Basic Trans Science 2020

Funding

  • ANR
  • CHU Nantes
  • Fondation pour la Recherche Médicale
  • Fédération Française de Cardiologie




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Updated on 28 July 2025.