Cardiac valve disease

Romain Capoulade & Solena Le Scouarnec


Investigators: Romain Capoulade, Soléna Le Scouarnec, Jean Mérot, Jean-Jacques Schott, Thierry Le Tourneau, Claire Toquet, Jean-Christian Roussel
PhD students: Guillaume Guimbretière, Robin Le Ruz, Benjamin Le Vély, Marine Sallé
Support staff: Pascal AumondChristian Dina, Pierre Lindenbaum, Florence Kyndt

Cardiac valve diseases are the one of most frequent cardiovascular diseases and are associated with important mobi-mortality. There is currently no medical therapy available to at least slow down the progression of these pathologies, the only option remaining is to replace or repair the diseased valve, via surgical or transcatheter approaches.

In our group, we develop a translational research program, from the genetics and basic researches to the clinical setting, designed to improve our understanding on native valve diseases, such as calcific aortic valve stenosis (CAVS) and mitral valve prolapse (MVP), as well as structural bioprosthetic valve degeneration (SVD).

This program is declined around 3 main axes:

  • One of the largest worldwide cohorts of patients with valve diseases, with the recruitment of sporadic cases and large familial pedigrees.
  • Genetic investigations on familial and isolated cases presenting different degrees of valve diseases.
  • Study of the pathophysiological mechanisms leading to the initiation and progression of these cardiac valve diseases.

We are relying on in-house expertise on multi-omics and high-throughput genetic approaches, on established relevant cellular (primary cell culture and hiPSC) and animal (rodents and large animals) models, and on clinical & pre-clinical multimodal imaging. 

Learn more about our projects :

Selected Publications

Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study. Yu Chen H, Dina C, Small AM, Shaffer CM, Levinson RT, Helgadóttir A, Capoulade R, Munter HM, Martinsson A, Cairns BJ, Trudsø LC, Hoekstra M, Burr HA, Marsh TW, Damrauer SM, Dufresne L, Le Scouarnec S, Messika-Zeitoun D, Ranatunga DK, Whitmer RA, Bonnefond A, Sveinbjornsson G, Daníelsen R, Arnar DO, Thorgeirsson G, Thorsteinsdottir U, Gudbjartsson DF, Hólm H, Ghouse J, Olesen MS, Christensen AH, Mikkelsen S, Jacobsen RL, Dowsett J, Pedersen OBV, Erikstrup C, Ostrowski SR; Regeneron Genetics Center; O'Donnell CJ, Budoff MJ, Gudnason V, Post WS, Rotter JI, Lathrop M, Bundgaard H, Johansson B, Ljungberg J, Näslund U, Le Tourneau T, Smith JG, Wells QS, Söderberg S, Stefánsson K, Schott JJ, Rader DJ, Clarke R, Engert JC, Thanassoulis G. Eur Heart J. 2023 Jun

Multimodality imaging and transcriptomics to phenotype mitral valve dystrophy in a unique knock-in Filamin-A rat model. Delwarde C, Toquet C, Aumond P, Kayvanjoo AH, Foucal A, Le Vely B, Baudic M, Lauzier B, Blandin S, Véziers J, Paul-Gilloteaux P, Lecointe S, Baron E, Massaiu I, Poggio P, Rémy S, Anegon I, Le Marec H, Monassier L, Schott JJ, Mass E, Barc J, Le Tourneau T, Merot J, Capoulade R. Cardiovasc Res. 2023 May

The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration.Senage T*, Paul A*, Le Tourneau T*, Fellah-Hebia I, Vadori M, Bashir S, Galiñanes M, Bottio T, Gerosa G, Evangelista A, Badano LP, Nassi A, Costa C, Cesare G, Manji RA, Cueff de Monchy C, Piriou N, Capoulade R, Serfaty JM, Guimbretière G, Dantan E, Ruiz-Majoral A, Coste du Fou G, Leviatan Ben-Arye S, Govani L, Yehuda S, Bachar Abramovitch S, Amon R, Reuven EM, Atiya-Nasagi Y, Yu H, Iop L, Casós K, Kuguel SG, Blasco-Lucas A, Permanyer E, Sbraga F, Llatjós R, Moreno-Gonzalez G, Sánchez-Martínez M, Breimer ME, Holgersson J, Teneberg S, Pascual-Gilabert M, Nonell-Canals A, Takeuchi Y, Chen X, Mañez R, Roussel JC#, Soulillou JP#, Cozzi E#, Padler-Karavani V#. Nat Med. 2022 Feb

Genetic and In Vitro Inhibition of PCSK9 and Calcific Aortic Valve Stenosis. Perrot N, Valerio V, Moschetta D, Boekholdt SM, Dina C, Chen HY, Abner E, Martinsson A, Manikpurage HD, Rigade S, Capoulade R, Mass E, Clavel M-A, Le Tourneau T, Messika-Zeitoun D, Wareham NJ, Engert JC, Polvani G, Pibarot P, Esko T, Smith JG, Mathieu P, Thanassoulis G, Schott J-J, Bossé Y, Camera M, Thériault S, Poggio P, Arsenault BJ. J Am Coll Cardiol Basic Trans Science 2020

Primary cilia defects causing mitral valve prolapse. Toomer KA, Yu M, Fulmer D, Guo L, Moore KS, Moore R, Drayton KD, Glover J, Peterson N, Ramos-Ortiz S, Drohan A, Catching BJ, Stairley R, Wessels A, Lipschutz JH, Delling FN, Jeunemaitre X, Dina C, Collins RL, Brand H, Talkowski ME, Del Monte F, Mukherjee R, Awgulewitsch A, Body S, Hardiman G, Hazard ES, da Silveira WA, Wang B, Leyne M, Durst R, Markwald RR, Le Scouarnec S, Hagege A, Le Tourneau T, Kohl P, Rog-Zielinska EA, Ellinor PT, Levine RA, Milan DJ, Schott J-J*, Bouatia-Naji N*, Slaugenhaupt SA*, Norris RA*. Sci Transl Med 2019;


  • ANR
  • CHU Nantes
  • Région Pays de la Loire
  • Inserm
  • Fondation de France
  • Fondation pour la Recherche Médicale
  • Société Française de Cardiologie
  • Fédération Française de Cardiologie
  • Genavie

Mis à jour le 14 March 2024.